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Poloxamer Bioadhesive Hydrogel for Buccal Drug Delivery: Cytotoxicity and Trans-epithelial Permeability Evaluations Using Tr146 Human Buccal Epithelial Cell Line

Authors: Ni Zeng, Nathalie Mignet, Gilles Dumortier, Elodie Olivier, Johanne Seguin, Marc Maury, Daniel Scherman, Patrice Rat, Vincent Boudy

Journal: International journal of pharmaceutics (2015)

Institution: Paris Descartes University

Research Areas: Drug research

Cell Lines: Tr146 (Human buccal epithelial cell line)

Summary: The assessment of cell viability (MTT, Alamar Blue), membrane integrity (Neutral Red), and apoptosis assay (Hoechst 33342), were performed and associated with holomonitor M3 analysis.

Keywords: Holomonitor M3, Pluronic, Xanthan gum, Buccal tolerance, Necrosis, Apoptosis, Digital holographic microscopy, Drug development

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