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Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamos Cell Carcinom
Journal: Cancer Research (2012)
Institution: Lund university
Research Areas: Cancer research
Cell Lines: TE1 (Human squamous cell carcinoma of the esophagus)
Summary: Chondroitin and dermatan sulfate proteoglycans, which occur both in the matrix and at the cell surface, play important roles in thetumorgenic processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. IdoA in DS influences tumorigenesis by affecting cancer cell behavior